TOTAL SYNTHESIS OF CYCLOTHEONAMIDE-B, A FACILE ROUTE TOWARDS ANALOGS

Authors
BASTIAANS HMM VANDERBAAN JL OTTENHEIJM HCJ
Citation
Hmm. Bastiaans et al., TOTAL SYNTHESIS OF CYCLOTHEONAMIDE-B, A FACILE ROUTE TOWARDS ANALOGS, Tetrahedron letters, 36(33), 1995, pp. 5963-5966
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
33
Year of publication
1995
Pages
5963 - 5966
Database
ISI
SICI code
0040-4039(1995)36:33<5963:TSOCAF>2.0.ZU;2-A
Abstract
A flexible, convergent synthesis of Cyclotheonamide B (1b) was develop ed, starting from the constituent amino acids, using conventional benz yl-, t-butyl- and allyl-based protecting groups. By modification of th e key intermediates, this approach allows the preparation of cyclotheo namide analogues.