FLUOXETINE IMPROVES OUTCOME IN ADDICTED PATIENTS TREATED WITH OPIOID ANTAGONISTS

Authors
MAREMMANI I ZOLESI O DAINI L CASTROGIOVANNI P TAGLIAMONTE A
Citation
I. Maremmani et al., FLUOXETINE IMPROVES OUTCOME IN ADDICTED PATIENTS TREATED WITH OPIOID ANTAGONISTS, The American journal on addictions, 4(3), 1995, pp. 267-271
Citations number
14
Categorie Soggetti
Substance Abuse
Journal title
The American journal on addictions → ACNP
ISSN journal
10550496
Volume
4
Issue
3
Year of publication
1995
Pages
267 - 271
Database
ISI
SICI code
1055-0496(1995)4:3<267:FIOIAP>2.0.ZU;2-S
Abstract
A sample of 25 heroin-addicted patients, diagnosed according to DSM-II I-R criteria, were divided into two subgroups and treated with naltrex one alone or with a combination of naltrexone and fluoxetine. After 6 months of treatment, the 13 patients who received naltrexone in associ ation with the antidepressant showed a higher probability of abstinenc e from heroin compared with the 12 subjects treated with the narcotic antagonist alone. The possible mechanism of the fluoxetine effect is d iscussed.