L. Juslin et al., DROPLET SIZE MEASUREMENT .1. EFFECT OF 3 INDEPENDENT VARIABLES ON DROPLET SIZE DISTRIBUTION AND SPRAY ANGLE FROM A PNEUMATIC NOZZLE, International journal of pharmaceutics, 123(2), 1995, pp. 247-256
The effect of three independent variables (atomizing air pressure, flo
w rate of binder solution and polyvinylpyrrolidone concentration) on t
he droplet size distribution from a pneumatic nozzle was studied using
a normal 3(3) factorial design. The droplet sizes and size distributi
ons were determined by laser diffractometry. The effect of the same va
riables on the spray angle and cross-sectional area of spray cone (des
cribes the area of wetted bed in a fluidized bed granulator) was also
evaluated. The dependence of these latter response variables on the in
dependent variables was studied by a multilinear stepwise regression a
nalysis. It was noted that increasing the amount of polyvinylpyrrolido
ne in binder solution decreased the number of bimodal distributions an
d increased the width of the distributions. A high pressure with water
as a binder solution resulted in a pronounced bimodality and a narrow
width of distribution, Increasing the flow rate had no clear; effect
on the shape of distributions (uni- or bimodal), but the width of dist
ributions increased. The atomizing air pressure was the most significa
nt factor affecting the spray angle and the cross-sectional area of th
e spray cone. Increasing the pressure led to a decline in the spray an
gle and to a decreased area. The effect of PVP concentration was oppos
ite to that of pressure. The effect of flow rate was controversial bec
ause, according to the regression analyses, it affected inversely the
spray angle and the area.