DROPLET SIZE MEASUREMENT .2. EFFECT OF 3 INDEPENDENT VARIABLES ON PARAMETERS DESCRIBING THE DROPLET SIZE DISTRIBUTION FROM A PNEUMATIC NOZZLE STUDIED BY MULTILINEAR STEPWISE REGRESSION-ANALYSIS
L. Juslin et al., DROPLET SIZE MEASUREMENT .2. EFFECT OF 3 INDEPENDENT VARIABLES ON PARAMETERS DESCRIBING THE DROPLET SIZE DISTRIBUTION FROM A PNEUMATIC NOZZLE STUDIED BY MULTILINEAR STEPWISE REGRESSION-ANALYSIS, International journal of pharmaceutics, 123(2), 1995, pp. 257-264
The influence of three independent variables (atomizing air pressure,
flow rate of binder solution and polyvinylpyrrolidone concentration) o
n the parameters describing the droplet size distribution from a pneum
atic nozzle (volume of droplets under 18.9 mu m, median and 90% fracti
le of droplet size) was studied using a normal 3(3) factorial design.
The droplet size measurement was carried out by laser diffractometry.
The dependence of the response variables on the independent variables
was studied by a multilinear stepwise regression analysis. On the basi
s of this study, it was concluded that a high atomizing air pressure l
ed to an increased volume of small droplets. Thereafter, the polyvinyl
pyrrolidone concentration and the binder flow rate affected this respo
nse variable inversely. Increasing the atomizing air pressure resulted
in a fall in the droplet size. A larger droplet size was obtained wit
h increased binder now rate and polyvinylpyrrolidone concentration. In
addition to main and quadratic effects, the regression analyses revea
led some interactions between independent variables. For example, the
atomizing air pressure had a stronger effect on the median of droplet
size when the polyvinylpyrrolidone concentration was lower. This was s
upposed to be due to changes in viscosity.