We report the presence of antisulfatide antibodies in a patient with t
ype I Gaucher's disease and peripheral neuropathy. The association of
Gaucher's disease with hypergammaglobulinemia and monoclonal gammopath
y is well documented whereas its association with peripheral neuropath
y is rare. We discuss whether antibodies directed against the sulfatid
e antigen are related to Gaucher's disease or are a coincidental assoc
iation.