Purpose: To investigate the issue of incidental appendectomy during ur
ological surgery we retrospectively studied its consequences in 2 grou
ps of urological patients. Materials and Methods: We studied 147 patie
nts undergoing cystectomy and urinary diversion (group 1) and 200 unde
rgoing primary retroperitoneal lymphadenectomy (group 2). Incidental a
ppendectomy was performed in 122 (83%) and 114 (57%) patients, respect
ively. Results: The incidence of infectious complications in group 2 w
as significantly higher among patients who underwent incidental append
ectomy compared to those without appendectomy (9.6% and 2.3%, respecti
vely, p = 0.032). No difference was noted among the patients in group
1 (10.6% and 12,0%, respectively, p = 0.51). Conclusions: When evaluat
ing the prophylactic merits, incidental appendectomy can be performed
safely during radical cystectomy and urinary diversion. It is probably
contraindicated in patients undergoing retroperitoneal lymphadenectom
y for testis cancer due to the apparent added risk of infectious compl
ications.