CASE-CONTROL STUDY OF MATERNAL BLOOD-GROUP AND SEVERE PREECLAMPSIA

Citation
A. Spinillo et al., CASE-CONTROL STUDY OF MATERNAL BLOOD-GROUP AND SEVERE PREECLAMPSIA, Journal of human hypertension, 9(8), 1995, pp. 623-625
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
09509240
Volume
9
Issue
8
Year of publication
1995
Pages
623 - 625
Database
ISI
SICI code
0950-9240(1995)9:8<623:CSOMBA>2.0.ZU;2-H
Abstract
The relation of maternal blood group to pre-eclampsia has not been ade quately studied in previous research. To investigate this relation, we conducted a case-control study of primigravidae. Data on 204 consecut ive severely pre-eclamptic patients delivered pre-term and 744 control s were analysed using multivariate methods. After adjustment for the c onfounding effects of maternal age, social class, origin, education, p re-pregnancy weight and body mass index, and weight gain in pregnancy, we found an increased risk of pre-eclampsia for mothers with blood ty pe AB (adjusted odds ratio = 3.07; 95% confidence interval 1.48-6.36). With respect to blood group O, A, B and Rh type, no statistically sig nificant correlation with severe pre-eclampsia was found. Although the se results should be considered with caution, they support the hypothe sis of a linkage mechanism involving blood group in the inheritance of susceptibility to pre-eclampsia.