ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME-DD GENOTYPE WITH HYPERTENSION IN DIABETES

Angiotensin converting enzyme (ACE) genotypes have been associated wit h hypertension in the general population, However, the relation of ACE genotype to the prevalence of hypertension in diabetic populations is less clear. This study investigated ACE genotypes in 100 patients wit h diabetes mellitus, of whom 41 were on anti-hypertensive medication. A significant association was found between the presence of the ACE-D allele and hypertension in both the overall diabetic group (D=0.66, P< 0.01) and in the subset of diabetics who had non-insulin-dependent dia betes (D=0.69, P<0.001). There was no correlation of ACE genotype with hypertension in insulin-dependent diabetes (D=0.57).