5-ALPHA-ANDROSTAN-3-ALPHA,17-BETA-DIOL IS A HORMONE - STIMULATION OF CAMP ACCUMULATION IN HUMAN AND DOG PROSTATE

Authors
NAKHLA AM DING VDH KHAN MS ROMAS NA RHODES L SMITH RG ROSNER W
Citation
Am. Nakhla et al., 5-ALPHA-ANDROSTAN-3-ALPHA,17-BETA-DIOL IS A HORMONE - STIMULATION OF CAMP ACCUMULATION IN HUMAN AND DOG PROSTATE, The Journal of clinical endocrinology and metabolism, 80(7), 1995, pp. 2259-2262
Citations number
30
Categorie Soggetti
Endocrynology & Metabolism
Journal title
The Journal of clinical endocrinology and metabolism → ACNP
ISSN journal
0021972X
Volume
80
Issue
7
Year of publication
1995
Pages
2259 - 2262
Database
ISI
SICI code
0021-972X(1995)80:7<2259:5IAH-S>2.0.ZU;2-O
Abstract
5 alpha-Androstan-3 alpha,17 beta-diol (3 alpha-diol) is a well known metabolite of dihydrotestosterone (DHT) and the concentration of its g lucuronide in serum is' looked upon as a marker of DHT activity in ski n and prostate. The data in this communication show that 3 alpha-diol is a potent agonist of the human and canine prostatic SHBG-[SHBG recep tor]. It causes a robust rise in intracellular cAMP within minutes; th e 1/2 max. response occurs at a concentration equal to its concentrati on in male plasma. Estradiol is the only other agonist in this system. All other steroids that bind to SHBG are antagonists.