CENTRAL AND PERIPHERAL DOPAMINE D-1 DA(1) RECEPTOR MODULATION OF GASTRIC-SECRETION AND EXPERIMENTAL GASTRIC-MUCOSAL INJURY/

1. Dopamine D-1 (central)/DA(1) (peripheral) receptors are believed to influence gastrointestinal function and pathology. 2. When given i.c. v. or i.p., an agonist (SKF38393) and an antagonist (SCH23390) of this DA receptor subtype inhibit and enhance, respectively, gastric secret ion and gastric mucosal injury. 3. When given both i.c.v. and i.p., th eir respective effects in the gut were amplified. 4. Antagonist or ago nist given i.p., blocked the corresponding protective and worsening ef fect of the agonist or antagonist given i.c.v. 5. Both central and per ipheral D-1/DA(1) receptors modulate gastric function and response to injury.