INSULINOTROPIC ACTION OF -2-BENZYL-3-(CIS-HEXAHYDRO-2-ISOINDOLINYLCARBONYL) PROPIONATE .2. IONOPHORETIC AND CONFORMATIONAL ASPECTS

Authors
MALAISSE WJ NADI AB MALAISSELAGAE F SATO F LINS L BRASSEUR R
Citation
Wj. Malaisse et al., INSULINOTROPIC ACTION OF -2-BENZYL-3-(CIS-HEXAHYDRO-2-ISOINDOLINYLCARBONYL) PROPIONATE .2. IONOPHORETIC AND CONFORMATIONAL ASPECTS, General pharmacology, 26(6), 1995, pp. 1319-1325
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
6
Year of publication
1995
Pages
1319 - 1325
Database
ISI
SICI code
0306-3623(1995)26:6<1319:IAO->2.0.ZU;2-1
Abstract
1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-( cis -hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane mo del. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable at tributes for ionophoretic activity across a hydrophobic environment. 3 . It is speculated that the ionophoretic property of KAD-1229 might pa rticipate to the remodelling of cationic fluxes evoked by this insulin otropic agent in pancreatic islet cells.