TREATMENT WITH ACARBOSE, AN ALPHA-GLUCOSIDASE INHIBITOR, REDUCES INCREASED ALBUMIN EXCRETION IN STREPTOZOTOCIN-DIABETIC RATS

Authors
COHEN MP VASSELLI JR NEUMAN RG WITT J
Citation
Mp. Cohen et al., TREATMENT WITH ACARBOSE, AN ALPHA-GLUCOSIDASE INHIBITOR, REDUCES INCREASED ALBUMIN EXCRETION IN STREPTOZOTOCIN-DIABETIC RATS, General pharmacology, 26(6), 1995, pp. 1355-1361
Citations number
45
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
6
Year of publication
1995
Pages
1355 - 1361
Database
ISI
SICI code
0306-3623(1995)26:6<1355:TWAAAI>2.0.ZU;2-I
Abstract
1. We examined the effect of the alpha-glucosidase inhibitor acarbose on urinary albumin excretion (UAE) in streptozotocin diabetic rats. 2. Treatment with acarbose for 8 weeks after induction of diabetes preve nted the significant increase in UAE observed in untreated diabetic ra ts relative to nondiabetic controls. 3. Acarbose significantly reduced integrated glycemia, which correlated with albumin excretion rates, a nd exerts a salutary effect on diabetic renal dysfunction.