We describe a 73-year-old forest owner with widespread erythema, myalg
ia, and proximal muscle weakness, The clinical signs and the results o
f electromyography, magnetic resonance imaging, and a muscle biopsy we
re consistent with dermatomyositis, However, serology was positive for
Borrelia burgdorferi. More importantly, B burgdorferi DNA was detecte
d in skin by polymerase chain reaction techniques, and spirochete-like
organisms were detected in the muscle by silver staining. Lyme diseas
e with muscle involvement can mimic or trigger dermatomyositis and sho
uld be considered in the differential diagnosis of dermatomyositis.