MICROENCAPSULATION BY COACERVATION OF POLY(LACTIDE-CO-GLYCOLIDE) .4. EFFECT OF THE PROCESSING PARAMETERS ON COACERVATION AND ENCAPSULATION

Authors
NIHANT N GRANDFILS C JEROME R TEYSSIE P
Citation
N. Nihant et al., MICROENCAPSULATION BY COACERVATION OF POLY(LACTIDE-CO-GLYCOLIDE) .4. EFFECT OF THE PROCESSING PARAMETERS ON COACERVATION AND ENCAPSULATION, Journal of controlled release, 35(2-3), 1995, pp. 117-125
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Journal of controlled release → ACNP
ISSN journal
01683659
Volume
35
Issue
2-3
Year of publication
1995
Pages
117 - 125
Database
ISI
SICI code
0168-3659(1995)35:2-3<117:MBCOP.>2.0.ZU;2-C
Abstract
Attention has been paid to phase separation of poly(lactide-co-glycoli de) solutions in CH2Cl2 induced by the addition of a silicone oil in o rder to promote protein microencapsulation. Since the process is very fast, the system is anytime out of equilibrium The effect of the main processing parameters on the microencapsulation process has been analy zed and has highlighted that kinetics of the main encapsulation steps has a great effect on the characteristics of the final microspheres. T hese results have been discussed on the basis of a physico-chemical st udy of coacervation reported in previous papers of this series.