RS-33295-198 - A NOVEL, POTENT MODULATOR OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG-RESISTANCE

Authors
SLATE DL BRUNO NA CASEY SM ZUTSHI N GARVIN LJ WU H PFISTER JR
Citation
Dl. Slate et al., RS-33295-198 - A NOVEL, POTENT MODULATOR OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG-RESISTANCE, Anticancer research, 15(3), 1995, pp. 811-814
Citations number
20
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
15
Issue
3
Year of publication
1995
Pages
811 - 814
Database
ISI
SICI code
0250-7005(1995)15:3<811:R-ANPM>2.0.ZU;2-I
Abstract
A novel multidrug resistance modulator; RS-33295-198, circumvented dru g resistance in human, mouse, and Chinese hamster cell lines overexpre ssing P-glycoprotein. It enhanced the antiproliferative activity of do xorubicin, vincristine, etoposide, and paclitaxel and increased doxoru bicin retention in multidrug-resistant hamster CH(R)C5 cells. RS-33295 -198 modulated doxorubicin resistance in a murine P388/ADR leukemia mo del when administered ip via continuous minipump delivery, ip by bolus injection and orally; it also improved the efficacy of vincristine to ward P388/VCR leukemia when given ip or po. RS-33295-198 showed weak a ctivity in enhancing doxorubicin efficacy against a multidrug-resistan t human sarcoma xenograft.