TRANSCRIPTION FACTORS - STRUCTURE, FUNCTION, AND IMPLICATION IN MALIGNANT GROWTH

Transcription factors are the principal modulators of gene expression patterns in the organism and are thus involved in processes leading to changes in developmental programmes, responses to growth and differen tiation signals, and some of the alterations causing neoplastic transf ormation. The present overview deals with general aspects of the struc ture, function, and regulation of transcription factors, in relation t o their physiological role and oncogenic potential.