We made an MR-compatible brain slice holder that ensures that the imag
es have the same location and orientation as the subsequent histologic
sections. This device encloses the unfixed tissues, thus reducing the
danger of exposure to pathogens, MR imaging time is saved by scanning
selected slices rather than the whole brain; this technique is especi
ally useful when brain sections at varying angles, rather than paralle
l slices, are taken.