MASTERING THE LORE OF PROTEIN-STRUCTURE

A detailed description of the design, operation and capabilities of LO RE, a protein-database management tool to supplement more traditional protein map-fitting and model-building programs, is presented. The pro gram includes elements for searching the library of known crystal stru ctures for substructures of similar geometry. Substructures may be as simple as a single hairpin turn, or as complicated as an assembly of d ifferent elements of secondary structure. The programs also include el ements for manipulating structural segments in complex ways to enable a sophisticated molecular editing capability of enormous utility in mo deling and structure-refinement applications.