STRUCTURES OF 4 METHYLTETRAZOLE-CONTAINING ANTIVIRAL COMPOUNDS IN HUMAN RHINOVIRUS SEROTYPE-14

Authors
GIRANDA VL RUSSO GR FELOCK PJ BAILEY TR DRAPER T ALDOUS DJ GUILES J DUTKO FJ DIANA GD PEVEAR DC MCMILLAN M
Citation
Vl. Giranda et al., STRUCTURES OF 4 METHYLTETRAZOLE-CONTAINING ANTIVIRAL COMPOUNDS IN HUMAN RHINOVIRUS SEROTYPE-14, Acta crystallographica. Section D, Biological crystallography, 51, 1995, pp. 496-503
Citations number
40
Categorie Soggetti
Crystallography,"Biochemical Research Methods",Biology
Journal title
Acta crystallographica. Section D, Biological crystallography → ACNP
ISSN journal
09074449
Volume
51
Year of publication
1995
Part
4
Pages
496 - 503
Database
ISI
SICI code
0907-4449(1995)51:<496:SO4MAC>2.0.ZU;2-U
Abstract
Four novel antiviral WIN compounds, that contain a methyl tetrazole ri ng as well as isoxazole, pyridazine or acetylfuran rings, have had the ir structures determined in human rhinovirus serotype 14 at 2.9 Angstr om resolution. These compounds bind in the VP1 hydrophobic pocket, but are shifted significantly towards the pocket pore when compared to pr eviously examined WIN compounds. A putative water network at the pocke t pore is positioned to hydrogen bond with these four WIN compounds, a nd this network can account for potency differences seen in structural ly similar WIN compounds.