BENZOIC-ACID INHIBITORS OF INFLUENZA-VIRUS NEURAMINIDASE

Authors
LUO M JEDRZEJAS MJ SINGH S WHITE CL BROUILLETTE WJ AIR GM LAVER WG
Citation
M. Luo et al., BENZOIC-ACID INHIBITORS OF INFLUENZA-VIRUS NEURAMINIDASE, Acta crystallographica. Section D, Biological crystallography, 51, 1995, pp. 504-510
Citations number
21
Categorie Soggetti
Crystallography,"Biochemical Research Methods",Biology
Journal title
Acta crystallographica. Section D, Biological crystallography → ACNP
ISSN journal
09074449
Volume
51
Year of publication
1995
Part
4
Pages
504 - 510
Database
ISI
SICI code
0907-4449(1995)51:<504:BIOIN>2.0.ZU;2-4
Abstract
A strategy was developed to design non-carbohydrate inhibitors of infl uenza virus neuraminidase. Using an iterative cycle of modeling, synth esis, biological testing and X-ray crystallography structure determina tion, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.