AN (A-C)(N) DINUCLEOTIDE REPEAT POLYMORPHIC MARKER AT THE 5'-END OF THE ALDOSE REDUCTASE GENE IS ASSOCIATED WITH EARLY-ONSET DIABETIC-RETINOPATHY IN NIDDM PATIENTS

Authors
KO BCB LAM KSL WAT NMS CHUNG SSM
Citation
Bcb. Ko et al., AN (A-C)(N) DINUCLEOTIDE REPEAT POLYMORPHIC MARKER AT THE 5'-END OF THE ALDOSE REDUCTASE GENE IS ASSOCIATED WITH EARLY-ONSET DIABETIC-RETINOPATHY IN NIDDM PATIENTS, Diabetes, 44(7), 1995, pp. 727-732
Citations number
40
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Journal title
Diabetes → ACNP
ISSN journal
00121797
Volume
44
Issue
7
Year of publication
1995
Pages
727 - 732
Database
ISI
SICI code
0012-1797(1995)44:7<727:A(DRPM>2.0.ZU;2-N
Abstract
To study the relationship between the aldose reductase gene and diabet ic complications, an (A-C)(n) dinucleotide repeat sequence 2.1 kb upst ream of the transcription start site of this gene was identified and s tudied. There are seven alleles at this locus with a polymorphism info rmation content of 0.73 and a heterozygosity of 0.77 among tile Chines e population in Hong Kong. One of the alleles (2-2) was found to be as sociated with early onset of retinopathy in patients with non-insulin- dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the dose vicinity may be involved in the pathogenesis of this diabetic complication.