Y. Machida et al., ENANTIOMERIC SEPARATION OF DIOLS AND BETA-AMINO ALCOHOLS BY CHIRAL STATIONARY-PHASE DERIVED FROM (R,R)-TARTRAMIDE, Journal of chromatography, 757(1-2), 1997, pp. 73-79
Citations number
15
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
A novel chiral stationary phase (CSP) having a (R,R)-tartramide deriva
tive as a chiral moiety was synthesized. This CSP showed good chiral r
ecognition for 1,2-diols, bi-beta-naphthol and beta-amino alcohols (be
ta-blockers) without any derivatization. The driving force of enantiom
eric separation was assumed to be the dual hydrogen-bonding associatio
n and pi-pi interaction between the solute enantiomers and the chiral
moiety of CSP.