LIPID-PEROXIDATION PRODUCTS AND CHANGES IN PHOSPHOLIPID-COMPOSITION INDUCED BY INDOBUFEN IN DIABETIC PLATELETS

Authors
DMOSZYNSKA A WALTERCRONECK A LEDWOZYW A
Citation
A. Dmoszynska et al., LIPID-PEROXIDATION PRODUCTS AND CHANGES IN PHOSPHOLIPID-COMPOSITION INDUCED BY INDOBUFEN IN DIABETIC PLATELETS, Thrombosis research, 79(5-6), 1995, pp. 483-490
Citations number
28
Categorie Soggetti
Hematology,"Cardiac & Cardiovascular System","Peripheal Vascular Diseas
Journal title
Thrombosis research → ACNP
ISSN journal
00493848
Volume
79
Issue
5-6
Year of publication
1995
Pages
483 - 490
Database
ISI
SICI code
0049-3848(1995)79:5-6<483:LPACIP>2.0.ZU;2-B
Abstract
Indobufen is an antiaggregatory drug which first of all inhibits plate let aggregation by interfering with cyclooxygenase enzymes in platelet s. We have investigated the influence of indobufen (200 mg twice daily for 10 days) on platelet lipid peroxidation and phospholipid metaboli sm in diabetic patients. The production of lipid peroxidation products was significantly lower after drug treatment. Indobufen administratio n, however, had no influence on the fatty acid composition of platelet phospholipids.