We describe the isolation, cloning and sequencing of the cellobiohydro
lase 1 (EC 3.2.1.91)-encoding gene (cbh-1) of Neurospora crassa. The n
ucleotide and amino-acid sequences have high homology with the cbh-1 o
f Trichoderma reesei, Humicola grisea and Phanerochaete chrysosporium,
with clear signal, catalytic, hinge and substrate-binding domains in
that order. The EMBL database reference for this sequence is S42093.