EFFECT OF INTRAVENOUS GAMMA-GLOBULIN (IVIG) ON THE PLATELET COUNT IN PATIENTS WITH WISKOTT-ALDRICH SYNDROME

The ability of IVIG to increase platelet counts in patients with idiop athic thrombocytopenic purpura suggests its potential usefulness in ot her disease states characterized by low platelet counts. This possibil ity was evaluated in nine patients with the Wiskott-Aldrich syndrome ( WAS) who received IVIG, at a dose of 400 mg/kg every 4 weeks. The mean platelet count prior to institution of IVIG was 32,000/cumm (range 2, 400 to 98,000). Following administration of IVIG, the platelet count r anged between 5,000 and 85,000/cumm. There were no immediate increases in platelet counts after IVIG infusion in any patient who had serial platelet counts. During treatment, patients were not given any routine platelet transfusions for low platelet counts. However, while on IVIG , two patients showed a good response to platelet transfusion prior to surgical procedures. In conclusion, chronic IVIG therapy does not app ear to affect platelet counts in patients with the Wiskott-Aldrich syn drome.