COPPER(II) COMPLEXES OF 2-BENZOYLPYRIDINE N-4-SUBSTITUTED THIOSEMICARBAZONES

2-Benzoylpyridine N-4-substituted thiosemicarbazones commonly coordina te as neutral tridentate ligands to give five coordinate [Cu(HL)Cl-2] complexes when prepared in boiling isopropanol. However, when prepared in boiling ethanol, the anion (loss of the N-3-hydrogen) coordinates as a tridentate ligand to give [CuLCl] complexes. Representative cryst al structures of both stoichiometries have been determined. Spectral c haracterization of both the 2-benzoylpyridine N-4-substituted thiosemi carbazones and their copper(II) complexes includes IR, UV-vis, EPR and NMR studies. Growth inhibition studies of the thiosemicarbazones and their complexes were performed against two human pathogenic fungi.