Acute pain in infants is not assessed or managed optimally. The object
ives of the study were (a) to adapt a behavioral pain assessment measu
re (Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) for use
with infants, and (b) to establish the reliability and validity of th
e measure in a study of infants undergoing immunization. Ninety-six he
althy 4- to 6-month-old infants were randomized to receive either the
local anesthetic cream Eutectic Mixture of Local Anesthetics (EMLA) (N
= 49), or a placebo (N = 47) prior to immunization. The infant's beha
vioral response was videotaped immediately before and following the im
munization. Postprocedural pain scores were assessed from the videotap
e and were significantly lower in infants who received EMLA (P = 0.01)
. Pain scores were also significantly correlated with visual analogue
scale (VAS) scores assessed during vaccination. Five independent rater
s also independently rated ten infants to determine interrater reliabi
lity. Agreement between raters' scores was high (intraclass correlatio
n coefficient 0.95). Results from this study suggest that this measure
has beginning construct and concurrent validity and interrater reliab
ility when used in a research study. Further testing of the measure in
the clinical setting is required.