STUDIES ON THE ANTITUMOR 2,6-PIPERAZINEDIONES - SYNTHESIS OF 2,3-DIACETOXY-4-CARBOMETHOXY-(3',5'-DIOXO-N-4' SUBSTITUTED PIPERAZINYL METHYL)BENZENE

Authors
LI Q SHAO HW JIANG HL XIE YY
Citation
Q. Li et al., STUDIES ON THE ANTITUMOR 2,6-PIPERAZINEDIONES - SYNTHESIS OF 2,3-DIACETOXY-4-CARBOMETHOXY-(3',5'-DIOXO-N-4' SUBSTITUTED PIPERAZINYL METHYL)BENZENE, Die Pharmazie, 50(7), 1995, pp. 447-449
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
7
Year of publication
1995
Pages
447 - 449
Database
ISI
SICI code
0031-7144(1995)50:7<447:SOTA2->2.0.ZU;2-P
Abstract
The title compounds having the structure of etoxy-4-carbomethoxy-(3',5 '-dioxo-N-4'-substituted piperazinyl methyl) benzene were synthesized from 2-hydroxy-3-methoxybenzaldehyde in eight steps. Compound 9h showe d a potent inhibitory effect against P388 leukemia cells in vitro.