EFFECT OF DIFFERENT EXCIPIENTS ON RELEASE CHARACTERISTICS OF ACETYLSALICYLIC-ACID FROM COMPRESSED PELLETS

Authors
TORRADOSANTIAGO,"TORRADO JJ CADORNIGA R
Citation
Jj. Torradosantiago,"torrado et R. Cadorniga, EFFECT OF DIFFERENT EXCIPIENTS ON RELEASE CHARACTERISTICS OF ACETYLSALICYLIC-ACID FROM COMPRESSED PELLETS, Die Pharmazie, 50(7), 1995, pp. 476-478
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
7
Year of publication
1995
Pages
476 - 478
Database
ISI
SICI code
0031-7144(1995)50:7<476:EODEOR>2.0.ZU;2-3
Abstract
The release of actylsalicylic acid matrix tablets prepared from pellet s is studied with different hydrophilic excipients (microcrystalline c ellulose (MCC, Avicel(R) PH 101) wheat starch and dextrose monohydrate ) at different proportions. The release process is zero-order or first -order. Dissolution efficiency varied between 23 and 75% in 8 h. MCC i s the excipient with a higher compression protecting effect on the pel lets during tablet compaction. In vitro drug release depends on the MC C content of the tablets.