MASSIVE AMYLOID DEPOSITION IN PANCREATIC VIPOMA - A CASE-REPORT

We present a case of a pancreatic islet cell tumor, demonstrating typi cal clinical and immunohistochemical characteristics of a VIPoma, but with the novel feature of massive stromal amyloid deposition. Amyloid deposition has been reported in association with insulinomas of the pa ncreas, but as far as the available literature suggests, it has not be en reported in VIPomas. Islet associated polypeptide (IAPP) and calcit onin are both candidates for the amyloidogenic peptide in this case, b ased on observations in other tumors.