EXPERIMENTAL-STUDY OF INTERLEUKIN-1-BETA EFFECTIVENESS IN IRRADIATIONINJURY

Authors
LEGEZA VI CHIGAREVA NG PETKEVICH NV VASILYEVA TP ABDUL YA BOIKO VN
Citation
Vi. Legeza et al., EXPERIMENTAL-STUDY OF INTERLEUKIN-1-BETA EFFECTIVENESS IN IRRADIATIONINJURY, Gematologia i transfuziologia, 40(3), 1995, pp. 10-13
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
40
Issue
3
Year of publication
1995
Pages
10 - 13
Database
ISI
SICI code
0234-5730(1995)40:3<10:EOIEII>2.0.ZU;2-0
Abstract
The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discov ered that human recombinant inteleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Inte rleukin-1 beta reduced leukopenia and enhanced the recovery of bone ma rrow cell elements. The use of the preparation as an early pathogeneti c treatment of irradiation damage holds promise.