-1,2,3,4-TETRAHYDRO-2-NAPHTHALENAMINE-L-(-MANDELIC ACID (1())1) - THEABSOLUTE-CONFIGURATION OF A PRECURSOR OF THE ACTIVE STEREOISOMER OF 5,6-ADTN, AN IMPORTANT DOPAMINERGIC AGONIST/

Authors
FANTUCCI M MONTANARI S SANTANGELO F IANELLI S NARDELLI M
Citation
M. Fantucci et al., -1,2,3,4-TETRAHYDRO-2-NAPHTHALENAMINE-L-(-MANDELIC ACID (1())1) - THEABSOLUTE-CONFIGURATION OF A PRECURSOR OF THE ACTIVE STEREOISOMER OF 5,6-ADTN, AN IMPORTANT DOPAMINERGIC AGONIST/, Acta crystallographica. Section C, Crystal structure communications, 52, 1996, pp. 3147-3150
Citations number
37
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
52
Year of publication
1996
Part
12
Pages
3147 - 3150
Database
ISI
SICI code
0108-2701(1996)52:<3147:-A(-T>2.0.ZU;2-#
Abstract
The structure determination of the title compound, C12H18NO2+.C8H7O3-, has allowed the absolute configuration of the cation to be establishe d. The demethylated base, ,6-dihydroxy-1,2,3,4-tetrahydro-2-naphthalen amine, or (2S)-5,6-ADTN, is responsible for the dopaminergic activity; this work shows that it has the same spatial arrangement as (6aR)-apo morphine.