2'3'-DIDEOXY-3'-NITROTHYMIDINE AND 2'-PROPOXY-3'-NITROTHYMIDINE

Authors
NEIDLE S CHATTOPADHYAYA JP HOSSAIN N PAPCHIKHIN A
Citation
S. Neidle et al., 2'3'-DIDEOXY-3'-NITROTHYMIDINE AND 2'-PROPOXY-3'-NITROTHYMIDINE, Acta crystallographica. Section C, Crystal structure communications, 52, 1996, pp. 3173-3177
Citations number
15
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
52
Year of publication
1996
Part
12
Pages
3173 - 3177
Database
ISI
SICI code
0108-2701(1996)52:<3173:2A2>2.0.ZU;2-2
Abstract
The crystal structures of 2',3'-dideoxy-3'-nitrothymidine, C10H13N3O6 and 2'-propoxy-3'-nitrothymidine, C13H19N3O7, are reported. Both compo unds are analogous to the anti-HIV nucleoside 3'-azido-2',3'-dideoxyth ymidine (AZT). The replacement of the azido group in AZT by the nitro group in these two compounds has resulted in a sugar pucker preference of C2'-endo type, as observed in both structures, AZT itself and seve ral Of its derivatives.