CONTIGUOUS CLONE MAP OVER 3 MB ON THE LONG ARM OF CHROMOSOME-11 ACROSS A BALANCED TRANSLOCATION ASSOCIATED WITH SCHIZOPHRENIA

Forty-nine clones derived by microdissection of a schizophrenia-associ ated t(1;11)(q42.1;q14.3) breakpoint region have been assigned by soma tic cell hybrid mapping to seven discrete intervals on the long arm of human chromosome 11. Eleven of the clones were shown to map to a smal l region immediately distal to the translocation breakpoint on 11q. A 3-Mb contiguous clone map of this region was established by isolation of corresponding YAC recombinants. The contig was oriented and shown t o traverse the translocation breakpoint by FISH and microsatellite mar ker analysis. This contig will facilitate the isolation of candidate s equences whose expression may be affected by the translocation. (C) 19 95 Academic Press, Inc.