GENE STRUCTURE AND AMINO-ACID-SEQUENCE OF THE HUMAN CONE PHOTORECEPTOR CGMP-PHOSPHODIESTERASE ALPHA' SUBUNIT (PDEA2) AND ITS CHROMOSOMAL LOCALIZATION TO 10Q24

The genomic organization and nucleotide structure of the human cone ph otoreceptor cGMP phosphodiesterase alpha'-subunit (alpha'-PDE) gene (P DEA2) as well as its chromosomal localization have been determined. Th is gene, which spans about 48 kb, consists of 22 exons and codes for a n 858-amino-acid protein. The alpha'-PDE gene maps to human chromosome 10q24. Its coding region shows about 90% nucleotide identity and 93% amino acid identity with the corresponding region of the bovine gene. The intron-exon organization of the genes encoding human cone alpha'-P DE and rod beta-PDE are very similar, suggesting that these proteins h ave a close phylogenetic relationship and probably a common origin. (C ) 1995 Academic Press, Inc.