GENETIC-MAPPING OF THE MOUSE GENES ENCODING THE VOLTAGE-SENSITIVE CALCIUM-CHANNEL SUBUNITS

The genes encoding the alpha(1) and beta subunits of voltage-sensitive calcium channel were mapped in the mouse by analysis of the progeny o f two multilocus crosses. The alpha(1), beta(2), and beta(4) subunit g enes, termed Cchna1, Cchb2, and Cchb4, are located at different sites on proximal Chr 2, while the beta(3) subunit gene Cchb3 maps to Chr 15 near Wnt1. These results together with previous mapping data indicate that the calcium channel genes are dispersed in the mouse genome, unl ike the sodium channel genes, which are clustered. (C) Academic Press, Inc.