PRODUCTION OF BREFELDIN-A

Authors
MCCLOUD TG BURNS MP MAJADLY FD MUSCHIK GM MILLER DA POOLE KK ROACH JM ROSS JT LEBHERZ WB
Citation
Tg. Mccloud et al., PRODUCTION OF BREFELDIN-A, Journal of industrial microbiology, 15(1), 1995, pp. 5-9
Citations number
33
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of industrial microbiology → ACNP
ISSN journal
01694146
Volume
15
Issue
1
Year of publication
1995
Pages
5 - 9
Database
ISI
SICI code
0169-4146(1995)15:1<5:POB>2.0.ZU;2-G
Abstract
Fermentation conditions are described for the production of the antitu mor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eu penicillium brefeldianum, (B. Dodge) Stolk and Scott, ATCC 58665, An a nalytical hplc method was developed which allowed rapid quantitation o f the compound during fermentation. A kilogram of brefeldin-A was isol ated from a fermentation at the 6800-liter scale.