THE SYNERGISM BETWEEN BOVINE PAPILLOMAVIRUS TYPE-4 AND QUERCETIN IS DEPENDENT ON THE TIMING OF EXPOSURE

Authors
CAIRNEY M CAMPO MS
Citation
M. Cairney et Ms. Campo, THE SYNERGISM BETWEEN BOVINE PAPILLOMAVIRUS TYPE-4 AND QUERCETIN IS DEPENDENT ON THE TIMING OF EXPOSURE, Carcinogenesis, 16(8), 1995, pp. 1997-2001
Citations number
34
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
16
Issue
8
Year of publication
1995
Pages
1997 - 2001
Database
ISI
SICI code
0143-3334(1995)16:8<1997:TSBBPT>2.0.ZU;2-P
Abstract
Exposure to the flavonoid quercetin and transfection with bovine papil lomavirus type 4 (BPV-4) DNA lead to oncogenic transformation of prima ry bovine cells. Here we show that the synergism between quercetin and BPV-4 (or its E7 oncogene) is stronger the shorter the interval betwe en the two treatments. Quercetin immortalizes transformed cells, confe rs anchorage-independent growth and induces tumorigenicity in cells tr ansfected only with the E7 oncogene.