GLUTATHIONE-S-TRANSFERASE GSTM1 NULL GENOTYPE IS NOT OVERREPRESENTED IN AUSTRALIAN PATIENTS WITH NEVOID BASAL-CELL CARCINOMA SYNDROME OR SPORADIC MELANOMA

Citation
Sm. Shanley et al., GLUTATHIONE-S-TRANSFERASE GSTM1 NULL GENOTYPE IS NOT OVERREPRESENTED IN AUSTRALIAN PATIENTS WITH NEVOID BASAL-CELL CARCINOMA SYNDROME OR SPORADIC MELANOMA, Carcinogenesis, 16(8), 1995, pp. 2003-2004
Citations number
10
Categorie Soggetti
Oncology
Journal title
ISSN journal
01433334
Volume
16
Issue
8
Year of publication
1995
Pages
2003 - 2004
Database
ISI
SICI code
0143-3334(1995)16:8<2003:GGNGIN>2.0.ZU;2-Z
Abstract
The GSTM1 gene on chromosome 1p encodes the carcinogen-detoxification enzyme, glutathione S-transferase (mu subclass), The homozygous null g enotype at this locus has been associated with increased susceptibilit y to malignancy, including some skin cancers, One hundred and twenty-f our Australian patients with sporadic melanoma and 62 with familial ba sal cell carcinomas (a feature of nevoid basal cell carcinoma syndrome , NBCCS) were examined for germline homozygous deletions of GSTM1 usin g multiplex polymerase chain reactions, The homozygous null genotype w as not overrepresented in either those with a single melanoma or in th e NBCCS cases, Nor did it significantly accelerate tumorigenesis in ei ther group, Analyses of much larger sample sizes will be required to i nvestigate the representation of the null genotype in patients with mu ltiple melanoma primaries and in those with melanoma coexisting with o ther non-cutaneous malignancies.