SYNTHESIS, CHARACTERIZATION, AND CRYSTAL-STRUCTURE OF [CU(CINOXACINATE)(2)]CENTER-DOT-2H(2O) COMPLEX - A SQUARE-PLANAR CUO4 CHROMOPHORE - ANTIBACTERIAL STUDIES

The structural and spectroscopic properties of a new copper (II) compl ex of cinoxacin (HCx) have been investigated. The complex [Cu(Cx)(2)]. 2H(2)O crystallizes in the monoclinic system, space group P2(1)/c. Th e cell dimensions are: a = 7.998(2), b = 7.622(1), c = 18.955(6) Angst rom, beta = 94.38(2)degrees, V = 1154.6(6) Angstrom(3), Z = 2. The str ucture was refined to R = 0.051. The crystal is composed of [Cu(Cx)(2) ] units and uncoordinated water molecules. The Cu(II) ion, at a center of symmetry, is coordinated to two cinoxacinate (Cx) ligands related by the inversion center. Each cinoxacinate acts as bidentate ligand bo nded to the cation through its carboxylate oxygen atom and through its exocyclic carbonyl oxygen atom, resulting in a CuO4 chromophore in a crystallographically planar configuration. The complex was screened fo r its activity against several bacteria, showing the same antimicrobia l activity as the corresponding ligand.