COOPERATION BETWEEN TRANSCRIPTION FACTORS REGULATES LIVER DEVELOPMENT

Citation
A. Aran et al., COOPERATION BETWEEN TRANSCRIPTION FACTORS REGULATES LIVER DEVELOPMENT, Biology of the neonate, 67(6), 1995, pp. 387-396
Citations number
46
Categorie Soggetti
Pediatrics
Journal title
ISSN journal
00063126
Volume
67
Issue
6
Year of publication
1995
Pages
387 - 396
Database
ISI
SICI code
0006-3126(1995)67:6<387:CBTFRL>2.0.ZU;2-W
Abstract
Characterization and cloning of liver-enriched transcription factors h ave provided the tools to study the regulation of liver differentiatio n. Characterization of the temporal and spatial expression of these fa ctors have shown a sequential order of appearance, in coordination wit h the expression of their target genes, during liver development. Evid ence has accumulated showing cooperation between distinct factors in r egulating liver-specific gene expression. Since each of these factors is not uniquely expressed in the liver, yet, the liver is the only tis sue that expresses all of these factors, the cooperation between the c oexisting liver-enriched factors could constitute the basis for the re gulation of liver-specific gene expression.