Jm. Goplerud et al., EFFECT OF NORDIHYDROGUAIARETIC ACID ON CEREBRAL BLOOD-FLOW AND METABOLISM DURING HYPOXIA IN NEWBORN PIGLETS, Biology of the neonate, 67(6), 1995, pp. 425-431
Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, was invest
igated for its effect on cerebral blood flow (CBF) and cortical oxygen
consumption during hypoxia in 9 anesthetized, ventilated newborn pigl
ets. CBF was measured by radioactive microspheres while brain cortical
metabolism was evaluated by continuous P-31-NMR spectroscopy. Five pi
glets were treated with NDGA (3 mg/kg i.v. in 50% ethanol as vehicle)
prior to hypoxia and had CBF measured before NDGA (control), 15 min af
ter NDGA (baseline) and then after 15 and 45 min of hypoxia following
NDGA. Another 4 piglets were treated with vehicle (2 ml/kg 50% ethanol
) under the same protocol. In the NDGA-treated piglets, cerebral corti
cal O-2 consumption for a given PCr/Pi was significantly increased (p
< 0.05) compared to Leukotrienes non-NDGA. Since NDGA inhibits product
ion of vasocon-stricting leukotrienes during hypoxia, cortical capilla
ry beds Microspheres otherwise constricted may be perfused following N
DGA, thus Cerebral metabolism increasing the O-2-consuming tissue area
.