Ia. Shibley et Sn. Pennington, SIGNALING PATHWAYS REGULATING ORNITHINE DECARBOXYLASE ACTIVITY IN THEEMBRYONIC CHICKEN, Biology of the neonate, 67(6), 1995, pp. 441-449
The pathways regulating ornithine decarboxylase (ODC) activity in the
chick embryo were studied to determine which kinase-signaling pathways
regulate ODC activity levels during development. Insulin-dependent ty
rosine kinase, protein kinase C and cAMP-dependent protein kinase were
activated by the addition of insulin, tetradecanoylphorbol-12,13-acet
ate, and forskolin, respectively. All three drugs increased ODC activi
ty and forskolin combined with insulin increased ODC activity above th
e increase caused by either drug alone. These results suggest that all
three signaling pathways regulate ODC activity during development and
that common intermediates exist among the pathways downstream of the
kinases.