VOLTAMMETRIC RESPONSIVE SENSORS FOR ORGANIC-COMPOUNDS BASED ON ORGANIZED SELF-ASSEMBLED LIPOYL-BETA-CYCLODEXTRIN DERIVATIVE MONOLAYER ON A GOLD ELECTRODE

Voltammetric responsive sensors based on organized self-assembled beta -cyclodextrin derivative monolayers on a gold electrode (beta-CD-SME) for electroinactive organic species were studied. Both theoretical con siderations and experimental results proved that the reduction in the oxidation peak current of the electroactive marker, ferrocene caboxyli c acid, at beta-CD-SME was proportional to the concentration of the ta rget molecule and the formation constant of the inclusion complexes wi th beta-CD. The application of the sensor as a detector for ursodeoxyc holic and dehydrocholic acids after capillary electrophoresis (CE) sep aration has been tested. This sensor provides an alternative approach for the detection of electroinactive organic species, and is expected to find application in liquid chromatography (LC) and CE detection.