A. Kapil et S. Sharma, EFFECT OF OLEANOLIC ACID ON COMPLEMENT IN ADJUVANT-INDUCED AND CARRAGEENAN-INDUCED INFLAMMATION IN RATS, Journal of Pharmacy and Pharmacology, 47(7), 1995, pp. 585-587
The present work was aimed at evaluating the influence of oleanolic ac
id on complement-related inflammation. In adjuvant-induced arthritis a
nd carrageenan-induced paw oedema in rats, oleanolic acid was found to
possess significant anti-inflammatory and complement-inhibitory activ
ities. The intraperitoneal injection of oleanolic acid (60 mg kg(-1),
twice a day), before and after Freund's Complete Adjuvant challenge an
d thereafter repeated for several days, significantly reduced foot-pad
thickness of experimental animal models and simultaneously reduced co
mplement activity. Oleanolic acid also produced marked reduction in co
mplement levels and inflammatory effects on carrageenan-induced paw oe
dema in rats when injected intraperitoneally (60 mg kg(-1), twice a da
y).