COMPARISON OF THE HYDROLYSIS OF CYCLIC MESO-DIESTERS WITH PIG-LIVER ESTERASE (PLE) AND RABBIT LIVER ESTERASE (RLE)

A series of cyclic dimethyl meso-dicarboxylates including three-, four -, five- and six-membered rings with various substituents as well as n orbornene derivatives were hydrolyzed with pig liver esterase and rabb it liver esterase. No obvious similarity concerning the determined ena ntioselectivities and reaction half life times was observed comparing the two enzymes. Pig liver esterase was more suitable for producing en antiomerically pure compounds hydrolysing cyclic meso-diesters, wherea s rabbit liver esterase showed acceptable ee values only in the case o f aliphatic small ring diesters.