Jc. Winters et R. Appell, PERIURETHRAL INJECTION OF COLLAGEN IN THE TREATMENT OF INTRINSIC SPHINCTERIC DEFICIENCY IN THE FEMALE-PATIENT, Urologic clinics of North America, 22(3), 1995, pp. 673-678
Female stress urinary incontinence may result from anatomic displaceme
nt of a normally functioning urethra or intrinsic sphincteric deficien
cy (ISD). Patients with a fixed, well supported urethra and ISD are ex
cellent candidates for the transurethral or periurethral injection of
collagen as treatment of their incontinence. Excellent success rates a
re achieved within one to three injections under local anesthesia, and
the complications associated with the procedure are minimal. Of the p
atients who achieve dryness, more than 50% remain dry two years follow
ing injection. Periurethral injection of collagen is a nonsurgical opt
ion in the management of female stress urinary incontinence.