CYCLOSPORINE-A PREVENTS THE FORMATION OF MITOCHONDRIAL CLUSTERS IN LIVER-CELLS

Under experimental conditions cyclosporin A has been shown to affect t he spatial structure of the mitochondrial apparatus of isolated liver of hibernating ground squirrels and white mongrel rats. Cyclosporin A inhibits the effect of integration of individual mitochondria via inte rmitochondrial septa contacts into the united mitochondrial clusters i n the liver from hibernating ground squirrels its well as from white m ongrel rats. As for the rats the effect of integration results from in cubation under experimental conditions.