DESIGN, SYNTHESIS, AND ANTI-TRYPANOSOMA CRUZI EVALUATION OF A NEW CLASS OF CELL-GROWTH INHIBITORS STRUCTURALLY RELATED TO FENOXYCARB

Authors
SCHVARTZAPEL AJ FICHERA L ESTEVA M RODRIGUEZ JB GROS EG
Citation
Aj. Schvartzapel et al., DESIGN, SYNTHESIS, AND ANTI-TRYPANOSOMA CRUZI EVALUATION OF A NEW CLASS OF CELL-GROWTH INHIBITORS STRUCTURALLY RELATED TO FENOXYCARB, Helvetica Chimica Acta, 78(5), 1995, pp. 1207-1214
Citations number
28
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
78
Issue
5
Year of publication
1995
Pages
1207 - 1214
Database
ISI
SICI code
0018-019X(1995)78:5<1207:DSAACE>2.0.ZU;2-I
Abstract
Several compounds, structurally related to the insect-growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were t ested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T.cruzi making t hem promising good candidates either for blood-bank sterilization or C hagas'-disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity.