Th. Douglas et al., EFFECT OF EXOGENOUS TESTOSTERONE REPLACEMENT ON PROSTATE-SPECIFIC ANTIGEN AND PROSTATE-SPECIFIC MEMBRANE ANTIGEN LEVELS IN HYPOGONADAL MEN, Journal of surgical oncology, 59(4), 1995, pp. 246-250
Previous studies have suggested that serum prostate-specific antigen (
PSA) levels are under androgenic influence, especially in patients wit
h adenocarcinoma of the prostate. PSMA (prostate-specific membrane ant
igen) is thought to reflect hormonal or clonal resistance or an indepe
ndence with respect to testosterone regulation. The influence of testo
sterone on serum PSA expression in normal men is not clear. We studied
the effect of exogenous testosterone administration on the serum leve
ls of PSA and PSMA in hypogonadal men. Serial serum PSA, serum PSMA by
Western blot, and serum total testosterone levels were obtained at in
tervals of every 2-4 weeks in 10 hypogonadal men undergoing treatment
with exogenous testosterone, delivered as testosterone enanthate injec
tion or by testosterone patch. Linear and quadratic orthogonal polynom
ial scores were calculated for PSMA, PSA, and testosterone. A 2-tailed
, paired t-test failed to demonstrate a significant correlation betwee
n serum PSA (linear P = 0.432, quadratic P = 0.290) or PSMA (linear P
= 0.162, quadratic P = 0.973) and serum testosterone levels. This stud
y suggests that in hypogonadal men, neither PSMA nor PSA expression is
testosterone-dependent, (C) 1995 Wiley-Liss, Inc.